BCL6 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66340-1-Ig |CloneNo.: 1E6B1

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Species specificity:
human

Positive WB detected in:
Ramos cells, Raji cells

Positive IHC detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:1000-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
B-cell CLL/lymphoma 6

Calculated molecular weight:
706aa,79 kDa

Observed molecular weight:
85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCL6

Synonyms
B cell CLL/lymphoma 6, B cell lymphoma 5 protein, B cell lymphoma 6 protein, BCL6, LAZ3, Protein LAZ 3, ZBTB27, Zinc finger protein 51, ZNF51
Background

BCl6, a zinc finger transcription factor, contains a N-terminal BTB/POZ domain and C-terminal zinc finger DNA-binding motifs and represses transcription of a wide range of target proteins and microRNAs. BCL6 protein has been reported as a master regulator of B lymphocyte development and growth, and altered BCL6 protein expression was implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL). BCL6 is required for the development of T follicular helper T cells (TFH), a helper T cell subset required for the formation of mature and productive GCs. BCL6 has also been shown to play important regulatory roles in macrophages.


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