CCR5 Polyclonal antibody

CCR5 Polyclonal Antibody for FC, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

FC, IHC, ELISA and More (1)

Conjugate

Unconjugated

Cat No : 17476-1-AP

Print datasheet

Synonyms

C C chemokine receptor type 5, C C CKR 5, CC CKR 5, CCCKR5, CCR 5, CCR5, CD195, CHEMR13, CKR 5, CKR5, CMKBR5, HIV 1 fusion coreceptor, IDDM22



经过测试的应用

Positive IHC detected inhuman tonsillitis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive FC detected inK-562 cells

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:400-1:1600
Flow Cytometry (FC)FC : 0.20 ug per 10^6 cells in a 100 µl suspension
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

17476-1-AP targets CCR5 in IHC, IF, FC, ELISA applications and shows reactivity with human samples.

Tested Applications FC, IHC, ELISA
Cited ApplicationsIF, IHC
Tested Reactivity human
Cited Reactivityhuman, macaque
Immunogen CCR5 fusion protein Ag11493 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name chemokine (C-C motif) receptor 5
Synonyms C C chemokine receptor type 5, C C CKR 5, CC CKR 5, CCCKR5, CCR 5, CCR5, CD195, CHEMR13, CKR 5, CKR5, CMKBR5, HIV 1 fusion coreceptor, IDDM22
Calculated Molecular Weight 352 aa, 41 kDa
GenBank Accession NumberBC038398
Gene Symbol CCR5
Gene ID (NCBI) 1234
RRIDAB_10895966
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP51681
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CCR5 (also known as CD195) is a member of the beta chemokine receptor family. This protein is expressed by T cells and macrophages and is known to be an important co-receptor for macrophage-tropic viruses, including HIV, to enter host cells. The natural chemokine ligands that bind to CCR5 include MIP-1-alpha, MIP-1-beta, MCP-2, and RANTES.

实验方案

Product Specific Protocols
IHC protocol for CCR5 antibody 17476-1-APDownload protocol
FC protocol for CCR5 antibody 17476-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanIF

Nat Biotechnol

Magnify is a universal molecular anchoring strategy for expansion microscopy

Authors - Aleksandra Klimas
humanIF

Nat Immunol

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.

Authors - Di Huang
human

J Biol Chem

Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys197 and by transmembrane protein aptamers that target it for lysosomal degradation.

Authors - Lisa M Petti

Sci Rep

PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.

Authors - Jing Li
human

Retrovirology

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice.

Authors - Qiaoqiao Xiao
human

Cell Death Dis

Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.

Authors - Haixu Xu