Cyclin D3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66357-1-Ig |CloneNo.: 1F2C6

Featured Product KD/KO validated

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human

Positive WB detected in:
Raji cells, Jurkat cells, HL-60 cells, HEK-293 cells, K-562 cells

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclin D3

Calculated molecular weight:
33 kDa

Observed molecular weight:
33-35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CCND3

Synonyms
CCND3, Cyclin D3, G1/S specific cyclin D3
Background

Cyclin D3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.


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