B23 Antibody 6 Publications

Mouse Monoclonal| Catalog number: 60096-1-Ig |CloneNo.: 4F12A3

Featured Product KD/KO validated

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HepG2 cells, C6 cells, ROS1728 cells, NIH/3T3 cells, RAW 264.7 cells, MCF-7 cells, HEK-293 cells, Jurkat cells

Positive IHC detected in:
human breast cancer tissue, human colon cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:5000-1:50000
IHC : 1:200-1:1000
IF : 1:50-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Calculated molecular weight:
33 kDa

Observed molecular weight:
35-38 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NPM1

Synonyms
B23, NPM, NPM1, Nucleophosmin, Numatrin
Background

Nucleophosmin (NPM1,B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.


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