Angiotensinogen Monoclonal antibody

Angiotensinogen Monoclonal Antibody for ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

ELISA

Conjugate

Unconjugated

CloneNo.

2H2A10

Cat No : 60126-1-Ig

Print datasheet

Synonyms

AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, Serpin A8, SERPINA8



经过测试的应用

Planning an IHC experiment? We recommend our IHCeasy AGT Ready-To-Use IHC Kit. AGT primary antibody included.

推荐稀释比

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

60126-1-Ig targets Angiotensinogen in applications and shows reactivity with human samples.

Tested Applications ELISA
Tested Reactivity human
Cited Reactivityhuman
Immunogen Angiotensinogen fusion protein Ag2632 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Synonyms AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, Serpin A8, SERPINA8
Calculated Molecular Weight 485 aa, 53 kDa
Observed Molecular Weight 52 kDa
GenBank Accession NumberBC011519
Gene Symbol AGT
Gene ID (NCBI) 183
RRIDAB_2225451
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP01019
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

发表文章

SpeciesApplicationTitle
human

Cells

Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation-Causing Autosomal Recessive Renal Tubular Dysgenesis.

Authors - Min-Hua Tseng