ASGR1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66692-1-Ig |CloneNo.: 1G5F5

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
Human, Mouse, Pig

Positive WB detected in:
pig liver tissue, L02 cells, HepG2 cells, human testis tissue, mouse hepatocytes

Recommended dilution:
WB : 1:1000-1:6000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
asialoglycoprotein receptor 1

Calculated molecular weight:
291aa,33 kDa

Observed molecular weight:
42 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ASGR1

Synonyms
ASGP R 1, ASGPR, ASGPR 1, ASGR1, asialoglycoprotein receptor 1, CLEC4H1, Hepatic lectin H1, HL 1, Hs.12056
Background

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.


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