BBS5 Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 14569-1-AP

Featured Product KD/KO validated

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue, human testis tissue, rat testis tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human testis tissue, human kidney tissue, human stomach tissue, human testis tissue

Positive IF detected in:
hTERT-RPE1 cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Bardet-Biedl syndrome 5

Calculated molecular weight:
39 kDa

Observed molecular weight:
40-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BBS5

Synonyms
Bardet Biedl syndrome 5, BBS5
Background

BBS5 encodes a protein that has been directly linked to Bardet-Biedl syndrome. Bardet-Biedl syndrome (BBS) is an autosomal recessive condition characterised by rod-cone dystrophy, postaxial polydactyly, central obesity, mental retardation, hypogonadism, and renal dysfunction. Other associated clinical findings in BBS patients include diabetes, hypertension and congenital heart defects. BBS expression varies both within and between families and diagnosis is often difficult. Experimentation in non-human eukaryotes suggests that BBS5 is expressed in ciliated cells and that it is required for the formation of cilia. Alternate transcriptional splice variants have been observed but have not been fully characterized.


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