Caspase 12 Antibody 19 Publications

Rabbit Polyclonal| Catalog number: 55238-1-AP

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, hamsters, mouse, rat

Positive WB detected in:
HEK-293 cells, multi-cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human prostate hyperplasia tissue, human heart tissue, human prostate hyperplasia tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
caspase 12 (gene/pseudogene)

Calculated molecular weight:
39 kDa

Observed molecular weight:
36-42 kDa, 50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASP12

Synonyms
CASP 12, CASP12, CASP12P1, caspase 12 (gene/pseudogene), Caspase12, Inactive caspase 12
Background

Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. Caspase-12 Antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa). This antibody does not cross-react with other caspases.


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