Caspase 8 Antibody 10 Publications

Mouse Monoclonal| Catalog number: 66093-1-Ig |CloneNo.: 2B9H8

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Species specificity:
human, monkey, mouse, sheep

Positive WB detected in:
HeLa cells, Jurkat cells, HeLa cells, HepG2 cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human liver cancer tissue, human liver tissue, human liver cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
caspase 8, apoptosis-related cysteine peptidase

Calculated molecular weight:
538aa,62 kDa

Observed molecular weight:
60,50,45,18 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASP8

Synonyms
Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5
Background

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 66093-1-AP can recognize pro- and cleaved-caspase 8.


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