CUL4B Antibody 15 Publications

Rabbit Polyclonal| Catalog number: 12916-1-AP

Featured Product KD/KO validated

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Species specificity:
human, mouse, dog, rat

Positive WB detected in:
HEK-293 cells, HeLa cells , mouse testis tissue, human testis tissue, SH-SY5Y cells, HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human gliomas tissue, human testis tissue

Positive IF detected in:
HepG2 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cullin 4B

Calculated molecular weight:
913aa,104 kDa

Observed molecular weight:
102 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CUL4B

Synonyms
CUL 4B, CUL4B, cullin 4B, DKFZp686F1470, KIAA0695, MRXHF2, MRXSC, SFM2
Background

Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes, including cell cycle progression, transcription, signal transduction and development (PMID: 21816341)(PMID: 21554755). Serving as the scaffold protein, cullins are crucial for the assembly of ligase complexes, which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse (PMID: 22606329).


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