DUSP2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 27327-1-AP

  • Print page
  • Download PDF

规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, mouse

Positive WB detected in:
A549 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dual specificity phosphatase 2

Calculated molecular weight:
34 kDa

Observed molecular weight:
34 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DUSP2

Synonyms
dual specificity phosphatase 2, DUSP2, PAC 1, PAC1
Background

DUSP2 belongs to the sub-family of nuclear specific DUSPs that includes DUSP1, 4 and 5. DUSP2 is highly expressed in immune cells, in particular, of patients with inflammatory arthritis, such as in rheumatoid arthritis (RA), and Dusp2 knockout mice present a significant reduction in inflammatory responses. It has been demonstrated that DUSP2 is a downstream target of the tumor suppressor p53 that is required for the cellular response to oxidative stress. DUSP2 is also involved in transcription factor E2F1–mediated apoptotic signaling. Like other members of the DUSP family, DUSP2 interacts with MAPKs; however, the target protein for its phosphatase activity is controversial.


Back
to top