Piezo1 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 15939-1-AP

Featured Product KD/KO validated

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, dog, mouse, zebrafish

Positive WB detected in:
HeLa cells, COLO 320 cells, HeLa cells, HepG2 cells, human brain tissue, HUVEC cells

Positive IHC detected in:
human skin tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
family with sequence similarity 38, member A

Calculated molecular weight:
286 kDa

Observed molecular weight:
230-280 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FAM38A

Synonyms
FAM38A, KIAA0233, Mib, PIEZO1
Background

Mechanotransduction, the conversion of mechanical force into biological signals, is a fundamental physiologic process of mammalian cells which influences many critical processes including embryonic development, tactile, pain, and auditory sensation, regulation of vascular tone, flow sensing in the kidney, and muscle and tendon stretch. FAM38A, also known as PIEZO1, has recently been identified as a mechanotransduction protein that gets involved in mechanosensation and stretch-activated cation channel activation. Fam38A also plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER. Mutations in gene encoding PIEZO1 are associated with hereditary xerocytosis. Piezo1 also regulates extrusion to maintain homeostatic epithelial cell numbers. The predicted MW of Piezo1 is 286 kDa, while some reports observed 230 kDa of Piezo1. (PMID: 20016066, 28416610)


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