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|Author:||Bardag-Gorce Fawzia F|
Exp Mol Pathol
Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo.
GADD45G, also named as CR6, DDIT2 and GRP17, is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.