Cytokeratin 1-specific Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 16848-1-AP

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, mouse

Positive WB detected in:
mouse skin tissue, A375 cells, A431 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human skin tissue, human cervix tissue, human lung cancer tissue, human skin tissue

Positive IF detected in:
A431 cells

Recommended dilution:
WB : 1:500-1:5000
IP : 0.5-4.0 ug for IP and 1:200-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
keratin 1

Calculated molecular weight:
66 kDa

Observed molecular weight:
67 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KRT1

Synonyms
67 kDa cytokeratin, CK 1, CK1, Cytokeratin 1, keratin 1, KRT1
Background

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. Keratin-1 is type II keratin. It is a specific marker for terminal differentiation in mammalian epidermis. It is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. This antibody is specifically against ketatin I.


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