SIK1 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 51045-1-AP

Featured Product KD/KO validated

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, mouse, rat

Positive WB detected in:
A549 cells, Jurkat cells

Positive IHC detected in:
human liver tissue, human lung cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
salt-inducible kinase 1

Calculated molecular weight:
783aa,85 kDa

Observed molecular weight:
85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SIK1

Synonyms
MSK, salt inducible kinase 1, SIK, SIK 1, SIK1, SNF1LK
Background

SIK1(Salt-inducible kinase 1) is also named as SIK, SNF1LK and belongs to the CAMK Ser/Thr protein kinase family. It associates constitutively with the NK regulatory complex and is responsible for increases in its catalytic activity following small elevations in intracellular sodium concentrations(PMID:17939993). SIK1 is required for phosphorylation of class II HDACs and for expression of MEF2 target genes in myocytes(PMID:17468767). Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers(PMID:19622832).


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