Breast Cancer Research focus
Breast cancer is the largest leading cause of death in women. It is not the primary breast tumor, but the metastases that are responsible for the high incidences of death. Although medical advances have been able to decrease the mortality rate, more and more women are developing breast cancer each year. (1)
HER2/ErbB2 (human epidermal growth factor) is a protein that can affect the growth of several cancer cells, and its overexpression has been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer (2) (3).
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| IHC staining of paraffin-embedded human breast cancer using HER2/ErbB2 antibody (51105-1-AP) at a dilution of 1:50 (40x objective). |
| Antibody Name | Cat No | Type |
| HER2/ErbB2 | 18299-1-AP | Rabbit Poly |
| HER2/ErbB2 | 51105-1-AP | Mouse Mono |
PAX8 is a member of the paired box (PAX) family, and is involved in oncogenesis. Several recent studies have shown that PAX8 facilitates important regulatory roles in breast cancer cell proliferation and tumor progression. (4) (5).
| Antibody Name | Cat No | Type |
| PAX8 | 10336-1-AP | Rabbit Poly |
| PAX8 | 60145-4-IG | Mouse Mono |
| PAX8-Specific | 66073-1-IG | Mouse Mono |
| Pan-PAX | 21383-1-AP | Rabbit Poly |
The estrogen receptor (ESR/ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Expression and mutation of ESR/ER are common features in breast cancer. (6) (7).
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| IHC staining of paraffin-embedded human breast cancer using ER antibody (21244-1-AP) at a dilution of 1.25 (40x objective). Heat mediated antigen retrieved with citric acid buffer, pH6.0. |
| Antibody Name | Cat No | Type |
| ESR/ER | 21244-1-AP | Rabbit Poly |
| Antibody Name | Cat No | Type |
| ADAM12 | 14139-1-AP | Rabbit Poly |
| COL1A2 | 14695-1-AP | Rabbit Poly |
| FKBPL | 10060-1-AP | Rabbit Poly |
| MMP-1 | 10371-2-AP | Rabbit Poly |
| PALLD | 10853-1-AP | Rabbit Poly |
| PR | 25871-1-AP | Rabbit Poly |
| PR | 66300-1-IG | Mouse Mono |
(1) Eifel P, et al. J. Natl Cancer Inst, 2001; 93: 979–989.
(2) Flavia F, et al. BMC Cancer, 2013; 19: 13: 81.
(3) Lu Y, et al. Oncotarget, 2016; Mar 16.
(4) Zhong X, et al. BMP Rep, 2011; 44: 595–600.
(5) Xia X, et al. Onc Letters, 2015; 29: 1501–06.
(6) Nadji M, et al. Am J Clin Path, 2005; 123: 21–7.
(7) Rhodes A, et al. J Clin Pathol, 2000; 53: 688–96.
