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ALLO-2

ALLO-2 是一种 Smo 耐药突变体的拮抗剂。在TM3-Gli-Luc 细胞中，它可抑制Smo 激动剂Hh-Ag1.5诱导的荧光素酶表达，其IC50=6 nM。

CAS号

1357350-60-7

分子式

C18H12F3N5O

主要靶点

Hedgehog/Smoothened|Smo

仅限科研使用

Cat No : CM17370

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Synonyms

验证数据展示

  • CAS No.: 1357350-60-7

    ALLO-2
    CAS#: 1357350-60-7

产品信息

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

CAS号 1357350-60-7
分子式 C18H12F3N5O
主要靶点 Hedgehog/Smoothened|Smo
主要通路 G蛋白偶联受体|干细胞
分子量 371.32
纯度 98.67%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:125 mg/mL (336.64 mM),Sonification is recommended.

参考文献

1.Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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