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Alvimopan

Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂，IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中，可用于术后肠梗阻的研究。

CAS号

156053-89-3

分子式

C25H32N2O4

主要靶点

Opioid Receptor

仅限科研使用

Cat No : CM11263

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Synonyms

爱维莫潘

验证数据展示

  • CAS No.: 156053-89-3

    Alvimopan
    CAS#: 156053-89-3

产品信息

Alvimopan is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.

CAS号 156053-89-3
分子式 C25H32N2O4
主要靶点 Opioid Receptor
主要通路 内分泌与激素|G蛋白偶联受体|神经科学
分子量 424.53
纯度 99.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 爱维莫潘

靶点活性

μ-opioid receptor:0.77 nM(Ki)|δ-opioid receptor:4.4 nM|δ-opioid receptor:4.4 nM(Ki)|κ-opioid Receptor:40 nM(Ki)

溶解度

DMSO:80 mg/mL(188.4 mM)

参考文献

1.Cassel JA, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):29-36.

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