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BMS-833923

BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂，以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合，IC50为21 nM。

CAS号

1059734-66-5

分子式

C30H27N5O

主要靶点

Hedgehog/Smoothened|Apoptosis|Smo

仅限科研使用

Cat No : CM06466

Print datasheet

Synonyms

XL-139

验证数据展示

  • CAS No.: 1059734-66-5

    BMS-833923
    CAS#: 1059734-66-5

产品信息

BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

CAS号 1059734-66-5
分子式 C30H27N5O
主要靶点 Hedgehog/Smoothened|Apoptosis|Smo
主要通路 干细胞|凋亡|G蛋白偶联受体
分子量 473.57
纯度 99.74%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 XL-139

靶点活性

BODIPY:21 nM

体内活性

BMS-833923剂量依赖性影响体外前列腺刺猬状信号基因的转录。BMS-833923使刺猬状通路活性降低、细胞增殖减少,并经内源性途径促使食管腺癌细胞系发生细胞凋亡。

溶解度

Ethanol:<1 mg/mL,DMSO:88 mg/mL (185.8 mM),H2O:<1 mg/mL

参考文献

1.Tang JY, et al. Semin Cutan Med Surg. 2011, 30(4 Suppl), S14-18. 2.Zaidi AH, et al. Cancer Invest. 2013, 31(7), 480-489. 3.Wilkinson SE, et al. Prostate. 2013, 73(16), 1810-1823.

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