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CUR61414

CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM)，并选择性地结合 smoothened (Ki = 44 nM)。

CAS号

334998-36-6

分子式

C31H42N4O5

主要靶点

Hedgehog/Smoothened

仅限科研使用

Cat No : CM13885

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Synonyms

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  • CAS No.: 334998-36-6

    CUR61414
    CAS#: 334998-36-6

产品信息

CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).

CAS号 334998-36-6
分子式 C31H42N4O5
主要靶点 Hedgehog/Smoothened
主要通路 G蛋白偶联受体|干细胞
分子量 550.69
纯度 97.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin[1].

体外活性

CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells[1].

溶解度

DMSO:90.9mg/mL (165.1mM),Sonification is recommended.

参考文献

1.Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4.
2.Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10.

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