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CUR61414 hydrochloride

CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM)，可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。

CAS号

分子式

C31H43ClN4O5

主要靶点

Hedgehog/Smoothened

仅限科研使用

Cat No : CM07387

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Synonyms

CUR61414 hydrochloride (334998-36-6 Free base)

验证数据展示

  • CAS No.:

    CUR61414 hydrochloride
    CAS#:

产品信息

CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively binds to smoothened (Smo, Ki= 44 nM). CUR61414 hydrochloride can induce cancer cells apoptosis without affecting neighboring non-tumor cells.

CAS号
分子式 C31H43ClN4O5
主要靶点 Hedgehog/Smoothened
主要通路 G蛋白偶联受体|干细胞
分子量 587.15
纯度 95.22%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CUR61414 hydrochloride (334998-36-6 Free base)

参考文献

1.Juliet A Williams, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.
2.Maria Frank-Kamenetsky. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002 Nov 6;1(2):10.

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