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Danegaptide Hydrochloride

Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) 是一种具有口服活性的间隙连接蛋白选择性修饰剂，具有抗心律不齐的作用。

CAS号

943133-81-1

分子式

C14H18ClN3O4

主要靶点

Gap Junction Protein

仅限科研使用

Cat No : CM16509

Print datasheet

Synonyms

GAP-134 (Hydrochloride)|ZP 1609 Hydrochloride|(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐

验证数据展示

  • CAS No.: 943133-81-1

    Danegaptide Hydrochloride
    CAS#: 943133-81-1

产品信息

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.

CAS号 943133-81-1
分子式 C14H18ClN3O4
主要靶点 Gap Junction Protein
主要通路 细胞骨架
分子量 327.76
纯度 99.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 GAP-134 (Hydrochloride)|ZP 1609 Hydrochloride|(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐

溶解度

DMSO:50 mg/mL (152.55 mM),H2O:50 mg/mL (152.55 mM)

参考文献

1.De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83.
2.Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8.
3.Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14.
4.Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.
5.Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2