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Histone H4 antibody (pAb)

Host / Isotype

Rabbit / Serum

Reactivity

Human, Wide Range Predicted

Applications

ChIP, WB

Cat No : 39070,39269,39270 39269

Synonyms

histone H4, histone, H4, histone-H4, histoneH4, pAb, polyclonal, antibody, antibodies, sample

验证数据展示

  • Histone H4 antibody (pAb) tested by Western blot. Detection of Histone H4 by Western blot. The analysis was performed using HeLa acid extract (20 ug) and probed with Histone H4 pAb at a 1:1,000 dilution.

    Histone H4 antibody (pAb) tested by Western blot. Detection of Histone H4 by Western blot. The analysis was performed using HeLa acid extract (20 ug) and probed with Histone H4 pAb at a 1:1,000 dilution.

产品信息

Tested Applications ChIP, WB

Applications Validated by Active Motif: WB: 1:500 - 1:2,000 dilution For Histone H4, we also offer AbFlex Histone H4 Recombinant Antibody (rAb). For details, see Catalog No. 91295.
Tested Reactivity Human, Wide Range Predicted
Host / Isotype Rabbit / Serum
Class Polyclonal
Type Antibody
Immunogen This Histone H4 antibody was raised against full-length recombinant Xenopus histone H4.
Full Name Histone H4 antibody (pAb)
Synonyms histone H4, histone, H4, histone-H4, histoneH4, pAb, polyclonal, antibody, antibodies, sample
Molecular weight 8 kDa
GenBank accession numberNP_001087926
RRIDAB_2636967
Purification Method None
Buffer Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. For your convenience, an IgG version (Catalog No. 61199) of this antibody that was purified by Protein A Chromatography is also available.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

Histone H4 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points; it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; they play a major role in regulating gene expression.