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Mocravimod hydrochloride

Mocravimod hydrochloride (KRP-203) 是 1-磷酸鞘氨醇受体 1 型 (S1PR1) 的有效和口服活性激动剂。

CAS号

509088-69-1

分子式

C24H27Cl2NO3S

主要靶点

LPL Receptor|Others

仅限科研使用

Cat No : CM16909

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Synonyms

KRP-203

验证数据展示

  • CAS No.: 509088-69-1

    Mocravimod hydrochloride
    CAS#: 509088-69-1

产品信息

Mocravimod hydrochloride is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).

CAS号 509088-69-1
分子式 C24H27Cl2NO3S
主要靶点 LPL Receptor|Others
主要通路 G蛋白偶联受体|其他
分子量 480.45
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 KRP-203

体内活性

In mHC-disparate rat heart allografts, Mocravimod hydrochloride(orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection[1]. Mocravimod hydrochloride ameliorates atherosclerosis in LDL-R(-/-) Mice[2].

溶解度

DMSO:95 mg/mL (197.73 mM),Sonification is recommended.

参考文献

1.Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R
2.Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2