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TfR-T12 acetate

TfR-T12 acetate 是一种与转铁蛋白受体 (TfR) 结合的肽，随后被内化到表达 TfR 的细胞中。

CAS号

分子式

C73H103N19O17S

主要靶点

Others

仅限科研使用

Cat No : CM12571

Print datasheet

Synonyms

TfR-T12 acetate (344618-30-0 Free base)

验证数据展示

  • CAS No.:

    TfR-T12 acetate
    CAS#:

产品信息

TfR-T12 acetate is a peptide binding to the transferrin receptor (TfR) and is subsequently internalized into TfR-expressing cells.

CAS号
分子式 C73H103N19O17S
主要靶点 Others
主要通路 其他
分子量 1550.78
纯度 97.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 TfR-T12 acetate (344618-30-0 Free base)

体内活性

In brain glioma-bearing mice, TfR-T12 acetate is transported across the BBB, killing brain glioma and glioma stem cells via the induction of necrosis, apoptosis and autophagy[2].

体外活性

TfR-T12 acetate can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[1].

参考文献

1.Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.
2.Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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