BCL2 Antibody 8 Publications

Mouse Monoclonal| Catalog number: 60178-1-Ig |CloneNo.: 4H8C6

Featured Product KD/KO validated

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Species specificity:
human, rat

Positive WB detected in:
Jurkat cells, HepG2 cells, U-937 cells, Jurkat cells

Positive IP detected in:
U-937 cells

Positive IHC detected in:
human tonsillitis tissue, human lymphoma tissue, human tonsillitis tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:1000-1:10000
IP : 0.5-4.0 ug for IP and 1:500-1:5000 for WB
IHC : 1:100-1:2000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
B-cell CLL/lymphoma 2

Calculated molecular weight:
26 kDa

Observed molecular weight:
26 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCL2

Synonyms
Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2
Background

BCL2 belongs to the Bcl-2 family. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. BCL2 regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).


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