验证数据展示
经过测试的应用
| Positive IHC detected in | human colon cancer tissue, human stomach cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| IHC | See 2 publications below |
| IF | See 1 publications below |
产品信息
19496-1-AP targets CEACAM3-Specific in IHC, IF, ELISA applications and shows reactivity with human samples.
| Tested Applications | IHC, ELISA Application Description |
| Cited Applications | IHC, IF |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | carcinoembryonic antigen-related cell adhesion molecule 3 |
| Synonyms | CEACAM3, W264, CGM1, CD66D, Carcinoembryonic antigen-related cell adhesion molecule 3 |
| Calculated Molecular Weight | 27 kDa |
| GenBank Accession Number | NM_001815 |
| Gene Symbol | CEACAM3 |
| Gene ID (NCBI) | 1084 |
| RRID | AB_2878582 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P40198 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CEACAM3, also named as CD66D and CGM1, belongs to the immunoglobulin superfamily and CEA family. CEACAM3 is the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species. CEACAM3 plays an important role in the clearance of pathogens by the innate immune system. It is responsible for RAC1 stimulation in the course of pathogen phagocytosis. The antibody is specific to isoform1 of CEACAM3.
实验方案
| Product Specific Protocols | |
|---|---|
| IHC protocol for CEACAM3-Specific antibody 19496-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Nat Commun Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma | ||
Cell Biosci Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis. |
