EPCAM Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66316-1-Ig |CloneNo.: 2A2D5

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Species specificity:
human

Positive WB detected in:
T-47D cells, A431 cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
MCF-7 cells, human colon cancer tissue

Recommended dilution:
WB : 1:2500-1:10000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
epithelial cell adhesion molecule

Calculated molecular weight:
314aa,35 kDa

Observed molecular weight:
35-40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EPCAM

Synonyms
CD326, CO 17A, CO17 1A, EGP, EGP 2, EGP314, EGP34, EGP40, Ep CAM, EPCAM, Epithelial glycoprotein, Epithelial glycoprotein 314, ESA, GA733 2, hEGP 2, hEGP314, KS 1/4 antigen, KS1/4, KSA, M1S2, M4S1, MIC18, MK 1, TACST 1, TACSTD1, TROP1
Background

Epithelial cell adhesion molecule (EpCAM, CD326) is a type I transmembrane glycoprotein that functions as a homophilic, epithelial-specific intercellular cell-adhesion molecule. In addition to cell adhesion, EpCAM is also involved in cellular signaling, cell migration, proliferation, and differentiation. EpCAM is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas, and has become a therapeutic target. EpCAM may occur in distinct forms due to glycosylation. (PMID: 20837599; 19249674; 21576002; 22647938; 12691820)


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