N-cadherin Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66219-1-Ig |CloneNo.: 1D8B3

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Species specificity:
human, pig, mouse, rat

Positive WB detected in:
human heart tissue, MKN-45 cells

Positive IHC detected in:
human heart tissue

Positive IF detected in:
mouse heart tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cadherin 2, type 1, N-cadherin (neuronal)

Calculated molecular weight:
906aa,100 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDH2

Synonyms
Cadherin 2, CD325, CDH2, CDHN, CDw325, N cadherin, NCAD, N-cadherin, Neural cadherin
Background

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a classical member of the cadherin superfamily which also include E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes (PMID: 11282032; 9508779; 8125202). N-cadherin has functions in early brain morphogenesis, synaptogenesis and synaptic plasticity (PMID: 23321619).


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