P53 Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60283-1-Ig |CloneNo.: 2D2F10

Featured Product KD/KO validated

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Species specificity:
human, mouse, rat

Positive WB detected in:
A431 cells, HEK-293 cells, COLO 320 cells, RAW 264.7 cells, NIH/3T3 cells, A431 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:2000-1:20000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tumor protein p53

Calculated molecular weight:
44 kDa

Observed molecular weight:
53 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TP53

Synonyms
Antigen NY CO 13, Cellular tumor antigen p53, FLJ92943, LFS1, Phosphoprotein p53, TRP53, tumor protein p53, Tumor suppressor p53
Background

TP53, also named as P53 and NY-CO-13, belongs to the p53 family. It has 9 isoforms. In SDS-Page, the MW is about 53kd. TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. The antibody reacts specifically with 53 kDa protein.


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