验证数据展示
产品信息
20658-1-AP targets PGC1a in WB, IF, IHC, chIP, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF, IHC, chIP |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse, rat, goat, chicken, zebrafish |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| 别名 | |
| 计算分子量 | 91 kDa |
| 观测分子量 | 91-98 kDa |
| GenBank蛋白编号 | NM_013261 |
| 基因名称 | PGC1a |
| Gene ID (NCBI) | 10891 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9UBK2 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PPARGC1A exists various isoforms and range of molecular weight of isoforms are 30-50 kDa and 90-110 kDa.
发表文章
| Species | Application | Title |
|---|---|---|
Redox Biol Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. | ||
Autophagy FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. | ||
Part Fibre Toxicol Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. | ||
Oxid Med Cell Longev Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy. | ||
Redox Biol Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro. |