验证数据展示
| Neutralization | Measured by its ability to neutralize Human beta-NGF induced proliferation of TF-1 cell line (human erythroleukemic cell line) . The half neutralization dose (ND50) is typically 4-20 ng/mL in the presence of 2 ng/mL human beta-NGF. |
产品信息
69009-1-Ig targets NeutraKine® Beta NGF in ELISA, Neutralization applications and shows reactivity with Human samples.
| 经测试应用 | ELISA, Neutralization Application Description |
| 经测试反应性 | Human |
| 免疫原 | human Humankine Beta NGF protein HZ-1222 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | nerve growth factor (beta polypeptide) |
| 别名 | Beta nerve growth factor, Beta NGF, HSAN5, NeutraKine® Beta NGF, NGF, NGFB, proNGF |
| 基因名称 | NGF |
| Gene ID (NCBI) | 4803 |
| RRID | AB_2882927 |
| 偶联类型 | Unconjugated |
| 形式 | Lyophilized Powder |
| 纯化方式 | Protein G purification |
| 储存缓冲液 | Sterile PBS. |
| 内毒素 | <0.1 EU/μg |
| 复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| 稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
Beta nerve growth factor (NGF) is critical for the survival and maintenance of sympathetic and sensory neurons and may play an important role in the regulation of the immune system (PMID 16842161). The presence of beta NGF in immune cells, endocrine cells, and the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body's response to stress (PMID 19442684).
This antibody can be used to neutralize the bioactivity of Beta NGF.