GDNF is essential for the development of theenteric nervous system. GDNF is a protein thatpromotes the survival and differentiation ofdopaminergic neurons in culture. It has thecapabilities of preventing apoptosis of motorneurons induced by axotomy. This productsignals through a receptor system which activatesreceptor tyrosine kinase RET signaling. The deathof the motor neurons may lead to diseases likeParkinson’s and ALS. GDNF is sought to haveregenerative properties specifically for braincells.