ACTN4 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66628-1-Ig |CloneNo.: 1E12B8

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
Human, Mouse, Rat

Positive WB detected in:
HEK-293 cells, HeLa cells, MCF-7 cells, Jurkat cells, HSCT6 cells, NIH/3T3 cells

Positive IHC detected in:
human lung cancer tissue, human breast cancer tissue

Recommended dilution:
WB : 1:5000-1:50000
IHC : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
actinin, alpha 4

Calculated molecular weight:
105 kDa

Observed molecular weight:
105 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ACTN4

Synonyms
ACTININ 4, actinin, alpha 4, ACTN4, Alpha actinin 4, F actin cross linking protein, FSGS, FSGS1, Non muscle alpha actinin 4
Background

ACTN4 (alpha actinin 4) is a ubiquitous actin-binding protein that cross-links actin filaments into bundles to form filopodia, and has a crucial role in cytoskeletal organization. ACTN4 is colocalized with actin stress fibers and is dispersed in the cytoplasm and in the nucleus. Increased levels of ACTN4 have been associated with cancer metastasis, indicating its implication in cancer cell migration and metastasis. Defects in ACTN4 cause glomerular disease. This antibody recognizes 105 kDa of endogenous ACTN4 protein in various lysates. (22370640, 10700177)


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