BAG6 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66661-1-Ig |CloneNo.: 1B8D3

  • Print page
  • Download PDF

规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
Human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, HSC-T6 cells, NIH/3T3 cells, HepG2 cells, Jurkat cells

Positive IHC detected in:
human breast cancer tissue, human testis tissue

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
HLA-B associated transcript 3

Calculated molecular weight:
119 kDa

Observed molecular weight:
150-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BAT3

Synonyms
BAG 6, BAG6, BAT3, D6S52E, G3, HLA B associated transcript 3, Protein G3
Background

BAT3 also known as Scythe or BAG6, is a nuclear protein implicated in the control of apoptosis and natural killer (NK) cell-dendritic cell (DC) interaction. BAT3 was first discovered as a member of a group of genes located within the class III region of the human major histocompatibility complex on chromosome 6, and has been extensively studied for its role in regulating apoptosis under various stress conditions such as DNA damage and endoplasmic reticulum-related stress. BAT3 has been shown to be required for p53 acetylation, which is critical for the enhancement of p53 transcriptional activity in response to DNA damage. In addition, BAT3 is involved in the regulation of development and reproduction of mammals by acting as a co-chaperone of the heat shock protein HSP70.


Back
to top