EGFR-Specific Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 18986-1-AP

  • Print page
  • Download PDF

Species specificity:
human, rat, mouse

Positive WB detected in:
L02 cells, multi-cells , HeLa cells, A431 cells, HeLa/RPE1 cells , A549 cells, MCF-7 cells

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human breast cancer tissue, human cervical cancer tissue

Positive IF detected in:
A431 cells

Positive FC detected in:
A431 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:200-1:2000 for WB
IHC : 1:400-1:1600
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Calculated molecular weight:
134 kDa

Observed molecular weight:
145-165 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EGFR

Synonyms
EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Proto oncogene c ErbB 1
Background

ERBB1, also mamed as EGFR, is a receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. ERBB1 is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. Isoform 2/truncated isoform of ERBB1 may act as an antagonist. EGFR is associated with lung cancer. The antibody is specific to isoform1.


Back
to top