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CoraLite®594-conjugated IFITM2 Polyclonal antibody
IFITM2 Polyclonal Antibody for FC (Intra)
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
FC (Intra)
Conjugate
CoraLite®594 Fluorescent Dye
验证数据展示
经过测试的应用
Positive FC detected in | MCF-7 cells |
For other applications, we recommend the unconjugated version of this antibody, 12769-1-AP
推荐稀释比
Application | Dilution |
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Flow Cytometry (FC) | FC : 0.40 ug per 10^6 cells in a 100 µl suspension |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
CL594-12769 targets IFITM2 in FC (Intra) applications and shows reactivity with human samples.
Tested Applications | FC (Intra) |
Tested Reactivity | human |
Immunogen | IFITM2 fusion protein Ag3451 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | interferon induced transmembrane protein 2 (1-8D) |
Synonyms | 1 8D, IFITM2 |
Calculated Molecular Weight | 132 aa, 15 kDa |
Observed Molecular Weight | 15 kDa |
GenBank Accession Number | BC009696 |
Gene Symbol | IFITM2 |
Gene ID (NCBI) | 10581 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q01629 |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. |
背景介绍
IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. Catalog#12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2.
实验方案
Product Specific Protocols | |
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FC protocol for CL594 IFITM2 antibody CL594-12769 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |