Lamin B1 Antibody 107 Publications

Rabbit Polyclonal| Catalog number: 12987-1-AP

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100 μl


500 μl


1000 μl


Species specificity:
human, mouse, rat, hamster, swine

Positive WB detected in:
HeLa cells, mouse eye tissue, mouse kidney tissue, NIH/3T3 cells, Y79 cells, K-562 cells, mouse lung tissue, human brain tissue, SH-SY5Y cells, Jurkat cells, rat brain tissue, mouse brain tissue, rat heart tissue, U-937 cells, human kidney tissue, HepG2 cells, mouse spleen tissue, mouse pancreas tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue, human kidney tissue

Positive IF detected in:
HepG2 cells, human skin cancer tissue, NIH/3T3 cells

Positive FC detected in:
HEK-293 cells

Recommended dilution:
WB : 1:1000-1:6000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
lamin B1

Calculated molecular weight:
66 kDa

Observed molecular weight:
66-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

ADLD, lamin B1, LMN, LMN2, LMNB, LMNB1

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Expression of uncleavable mutant lamin A or B caused significant delays in the onset of chromatin condensation and nuclear shrinkage during apoptosis(PMID:11953316). This protein is not suitable for samples where the nuclear envelope has been removed.

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