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NMDAR2B/GRIN2B Monoclonal antibody, PBS Only

NMDAR2B/GRIN2B Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C5E12

Cat No : 66565-1-PBS

Print datasheet

Synonyms

GluN2B, GRIN2B, hNR3, NMDAR2B, NMDAR2B/GRIN2B, NR2B, NR3

验证数据展示

  • WB analysis of mouse brain using 66565-1-Ig (same clone as 66565-1-PBS)

    WB analysis of mouse brain using 66565-1-Ig (same clone as 66565-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 66565-1-Ig (NMDAR2B/GRIN2B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66565-1-PBS in a different storage buffer formulation.

产品信息

66565-1-PBS targets NMDAR2B/GRIN2B in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB,Indirect ELISA
Tested Reactivity Human, Mouse, Rat
Immunogen NMDAR2B/GRIN2B fusion protein Ag16718 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Synonyms GluN2B, GRIN2B, hNR3, NMDAR2B, NMDAR2B/GRIN2B, NR2B, NR3
Calculated Molecular Weight 1484 aa, 166 kDa
Observed Molecular Weight 166 kDa
GenBank Accession NumberBC113620
Gene Symbol GRIN2B
Gene ID (NCBI) 2904
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ13224
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.