验证数据展示
产品信息
11592-1-AP targets NUAK2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human |
| 免疫原 | NUAK2 fusion protein Ag2031 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | NUAK family, SNF1-like kinase, 2 |
| 别名 | SNARK, OMPHK2, NUAK family SNF1-like kinase 2, NUAK 2, EC:2.7.11.1 |
| 计算分子量 | 628 aa, 70 kDa |
| 观测分子量 | 70 kDa |
| GenBank蛋白编号 | BC017306 |
| 基因名称 | NUAK2 |
| Gene ID (NCBI) | 81788 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9H093 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NUAK2(NUAK family SNF1-like kinase 2) is also named as OMPHK2, SNARK and belongs to the SNF1 subfamily. The function of NUAK2 is partly dependent on anti-apoptotic properties against apoptosis induced by death ligand and NUAK2 also has effects on the migration of cancer cells as speculated from studies on myosin filaments and cytoskeleton organization in normal cells(PMID:21911917). Western blot analysis detected NUAK2 expressed in cancer cell lines of diverse tissue origin(PMID:12409306).
发表文章
| Species | Application | Title |
|---|---|---|
Proc Natl Acad Sci U S A AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma. | ||
Cancer Res NUAK2 amplification coupled with PTEN deficiency promote melanoma development via CDK activation.
| ||
Diabetologia Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
| ||
Ann Clin Biochem Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients. |