SIX2 Antibody 95 Publications

Rabbit Polyclonal| Catalog number: 11562-1-AP

Featured Product KD/KO validated

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Species specificity:
human, mouse, rat, American alligator

Positive WB detected in:
HEK-293 cells, L02 cells, PC-3 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human kidney tissue, human renal cell carcinoma tissue

Positive IF detected in:
mouse embryonic kidney, heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice

"The Six2 antibody works great and is really specific to metanephricmesenchyme (kidney progenitor cells). We used it for IF and we highlyrecommend it!" Dr. Aleksandra Rak-Raszewska, University of Liverpool

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:100
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
SIX homeobox 2

Calculated molecular weight:
291aa,32 kDa

Observed molecular weight:
32-37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2

The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six members (Six1-Six6) of the Six gene family have been identified in mice and humans. SIX2, containing one homeobox DNA-binding domain, is highly expressed in fetal tissues but expression is limited in adult tissues. SIX2 may be involved in limb tendon and ligament development[PMID:21420949]. It has been previously shown that SIX2 is expressed in developing mesenchymal tissue including head and urogenital system at the time of overt midfacial and renal differentiation[PMID: 22282599]. This antibody is a rabbit polyclonal antibody raised against full length SIX2 of human origin.

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