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|Author:||María Ángeles Castilla|
Endocr Relat Cancer
Vgll1 expression is associated with a triple-negative basal-like phenotype in breast cancer.
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VGLL1 is a specific coactivator for the mammalian TEFs. It can bind proteins of the TEA domain family of transcription factors. Vgll1-TEFs complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation