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Recombinant human FGFbasic-TS™ is expressed in human 293 cells. FGFbasic is a heparin-binding growth factor and critical for human embryonic stem cells to remain in an undifferentiated state during cell culture. FGFbasic-TS™ is a protein engineered FGFbasic to enchance its thermo- stability without modification of biological function. FGFbasic-TS™ consists of 154 amino acids as a 17 kDa, non-glycosylated monomer.
Basic Fibroblast growth factor (FGFbasic), also known as bFGF, FGF2, FGF-β or HBGF-2, belongs to the FGF family. FGF-basic is involved in a number of biological processes including embryonic development and differentiation, neuron differentiation, survival, and regeneration, and the proliferation of cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin (PMID 3272178, 3316527). FGF-basic is critical for human embryonic stem cells to remain in an undifferentiated state during cell culture (PMID 15782187).