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Animal-free Recombinant Human PDGFaa is expressed in human 293 cells as a mixture of pro-dimers, pro-mature and mature dimers with an apparent molecular mass of 35 to 45 kDa. The cytokine is produced in a human cell expression system with serum free, chemically defined media.
PDGFaa is a member of the platelet-derived growth factor family. Four members of this family are mitogenic factors for cells of mesenchymal origin, and they are characterized by a motif of eight cysteines. PDGFaa plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, and chemotaxis. It is also required for a normal lung alveolar septum formation during embryogenesis, development of the gastrointestinal tract, and spermatogenesis. PDGFaa is also involved in oligodendrocyte development and l myelination process in the spinal cord and cerebellum PMID: 29408302; 29282077; 27002148).