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Animal-free Recombinant Human pro-IGF-II is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 25 kDa. Glycosylation contributes to stability in cell growth media and other applications. IGF-II expressed in E. coli is typically 7.5 kDa and nonglycosylated. This cytokine is produced in a human cell expression system with serum-free, chemically defined media.
IGF2 is a hormone involved in the regulation of cell proliferation, growth, migration, differentiation, and survival. IGF2 is mostly expressed in early embryonic and fetal development. Adult IGF2 expression occurs in the liver and epithelial cells lining the surface of the brain. IGF2 can also be detected in plasma (PMID: 24593700; 23257688)