BAX Antibody 7 Publications

Mouse Monoclonal| Catalog number: 60267-1-Ig |CloneNo.: 4G5E8

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, mouse, rat

Positive WB detected in:
MCF-7 cells, HEK-293 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human liver cancer tissue

Positive IF detected in:
MCF-7 cells, HeLa cells

Recommended dilution:
WB : 1:1000-1:10000
IHC : 1:400-1:1000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-associated X protein

Calculated molecular weight:
21 kDa

Observed molecular weight:
21 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BAX

Synonyms
Apoptosis regulator BAX, BAX
Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).


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