TIM3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60355-1-Ig |CloneNo.: 4C4G3

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规格

单价

50 μl

¥980

100 μl

¥1800

150 μl

¥2500


Species specificity:
human, pig, mouse, rat

Positive WB detected in:
Daudi cells, HEK-293 cells, human heart tissue, Jurkat cells, PC-3 cells, pig thymus tissue, rat heart tissue, RAW 264.7 cells, ROS1728 cells

Positive IHC detected in:
human lung cancer tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
hepatitis A virus cellular receptor 2

Calculated molecular weight:
301aa,33 kDa

Observed molecular weight:
33 kDa, 50-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HAVCR2

Synonyms
CD366, FLJ14428, HAVcr 2, HAVCR2, KIM 3, T cell membrane protein 3, Tim 3, TIM3, TIM-3, TIMD 3, TIMD3
Background

TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 (PMID: 20107545; 17069754; 11725301).


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