Histone-H3 Antibody 52 Publications

Rabbit Polyclonal| Catalog number: 17168-1-AP

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Species specificity:
human, mouse, rat, Xenopus laevis

Positive WB detected in:
MCF7 cells, HeLa cells, MCF-7 cells, mouse brain tissue, mouse kidney tissue, mouse liver tissue

Positive IHC detected in:
human skin cancer tissue, human breast cancer tissue

Positive IF detected in:
HEK-293 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
histone cluster 2, H3a

Calculated molecular weight:
136aa,15 kDa

Observed molecular weight:
15-17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HIST2H3A

Synonyms
H3/n, H3/o, H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D, histone cluster 2, H3a, Histone H3, Histone H3.2, Histone H3/m, Histone H3/o
Background

HIST2H3A,histone cluster 2, H3a.It is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST2H3A is Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.


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