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MRI study of cryoinjury infarction in pig hearts: i. Effects of intrapericardial delivery of bFGF/VEGF embedded in alginate beads.
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Animal-free Recombinant Human FGF-8b is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 30 to 45 kDa. This wide molecular mass is due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications. The cytokine is greater than 95% pure.
Fibroblast growth factor 8 (FGF8), also known as AIGF and HBGF-8, belongs to the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (PMID: 11276432; 15863033). FGF8 stimulates growth in an autocrine manner in normal individuals but mediates hormonal action during tumorigenesis (PMID 17512240). Defects in FGF8 cause Kallmann syndrome type 6 (KAL6) and idiopathic hypogonadotropic hypogonadism (IHH) (PMID 18596921).