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Animal-free Recombinant Human IL-28A (IFN lambda 2) is expressed in human 293 cells with an apparent molecular mass of 24 kDa. This cytokine is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic human post-translational modification which contributes to stability in cell growth media and other applications. The purity is greater than 95%.
IL28A is a type III IFN, which shares many of the biological effects of type I IFNs but may have fewer side effects due to a more selective receptor distribution. It interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). IL28A is believed to play a significant role in the antiviral immune defense in the intestinal epithelium (PMID: 20712453;12469119;16539846).